The Art of Science Learning (AOSL) is a National Science Foundation-funded initiative exploring innovation at the intersection of art, science and learning by using the arts to spark creativity in STEM education and foster the development of an innovative 21st Century STEM workforce. Our current project, funded by NSF grant DRL-1224111 (“Integrating Informal STEM and Arts-Based Learning to Foster Innovation”), has developed a new curriculum using the arts to teach innovation processes to adolescent and adult learners; implemented the curriculum in year-long arts-based Incubators for STEM Innovation; and studied arts-based learning’s impact on creative thinking skills, collaborative behaviors and innovation outcomes.