The Institute of Museum and Library Services’s Museums, Libraries, and 21st Century Skills initiative underscores the critical role our nation’s museums and libraries play in helping citizens build such 21st century skills as information, communications and technology literacy, critical thinking, problem solving, creativity, civic literacy, and global awareness. This report outlines a vision for the role of libraries and museums in the national dialogue around learning and 21st century skills and includes case studies of innovative audience engagement and 21st century skills practices from across the country.