In this study the effect of long-term physical and musical activity on spatial cognitive performance, measured by mental rotation performance, is investigated in detail. Mental rotation performance is the ability to rotate a three-dimensional object using the imagination. Three groups, each consisting of 40 students, and divided by the subjects, music, sports, and education, solved a psycho-metrical mental rotation task with three-dimensional block figures. According to Adrian, The results showed a better mental rotation performance for music and sports students compared to the education students. Furthermore, the well-known gender difference favoring males was found for both sports and education student,s but not for music students.